What is an autoimmune eye disease?
Your immune system is constantly working to find and destroy bacteria, viruses and other things that harm your health. But sometimes, people develop autoimmune disorders, which means the immune system starts mistakenly attacking the body's own cells. And some autoimmune disorders affect your eyes.
Symptoms of autoimmune eye diseases
Many autoimmune diseases can affect the eyes. Depending on the type, they might affect different parts of the eye and can have unique symptoms – it's not always obvious that they're being caused by an immune disorder. This is why it's important to get any changes in your eyes seen by a specialist.
We've listed some of the common autoimmune disease eye symptoms below. But be aware that not everyone gets all these symptoms.
Inflamed conjunctiva – The conjunctiva is a clear layer covering the whites of your eyes. If the conjunctiva is inflamed, more blood goes to the area, causing 'pink eye'.
Keratitis – This is when the cornea, the clear window that covers your iris and pupil, gets inflamed.
Watery eyes – Your eyes might be more watery than usual.
Vision changes – Conditions like diabetes, Graves’ disease, multiple sclerosis, lupus and Behçet’s disease can cause blurry or double vision, floaters, flashes or even sight loss. Learn more about diabetic retinopathy.
Red eye – Some immune disorders, like rheumatoid arthritis, Crohn’s and Sjögren’s syndrome, can cause keratoconjunctivitis, making eyes and eyelids red or bloodshot.
Eye swelling – During an immune disorder flare‑up, conditions like Graves’ disease and Hashimoto’s thyroiditis can make your eyes and eyelids swell.
Dry eyes – Conditions like Sjögren’s syndrome, coeliac disease, Guillain‑Barré syndrome, Graves’ disease and psoriasis can affect your tears, making your eyes feel very dry. Learn more about dry eye syndrome.
Eye pain – Immune disorders like rheumatoid arthritis can cause uveitis, which leads to a painful eye that’s sensitive to light. Multiple sclerosis eye symptoms can also include a painful ache in the eye when you look around.
Light sensitivity – Conditions like ankylosing spondylitis, juvenile idiopathic arthritis and dermatomyositis can make bright light uncomfortable for your eyes.
Other symptoms – Eye problems can be the first sign of an immune disorder, like early eye inflammation in multiple sclerosis. Many people also get tiredness, joint pain, skin rashes, fevers and more.
Types of autoimmune eye diseases
There are over 80 autoimmune disorders, and many kinds affect the eyes.
Reiter’s syndrome
Reiter’s syndrome (also known as reactive arthritis) is a type of inflammatory arthritis that affects the joints, eyes and urethra. It causes eye inflammation, which can lead to conjunctivitis and uveitis (inflammation of the middle layer of the eye).
Sjogren’s syndrome
Sjogren's syndrome is a chronic autoimmune disease that attacks the glands which keep the eyes, mouth and other parts of the body moist and lubricated. This makes them stop working so well and causes dry eyes.
Multiple sclerosis
Multiple sclerosis (MS) affects the brain, spinal cord, and optic nerve. Common eye symptoms include optic neuritis (inflammation of the optic nerve), nystagmus, and double vision.
Rheumatoid arthritis
Rheumatoid arthritis is known for affecting people's joints, but it can also affect the eyes – your eyes are made of similar tissues to your joints. It can cause dry eyes and inflammation of the sclera (the whites of your eyes).
Graves’ disease
Graves’ disease occurs when the immune system attacks the thyroid, causing hormone overproduction. This can lead to inflammation of the muscles and tissues around the eyes, resulting in bulging or puffy eyes.
Behçet's disease
A systemic autoimmune disease causing blood vessel inflammation throughout the body, including the eyes. It often causes eye inflammation, specifically uveitis and retinal vasculitis.
Sarcoidosis Sarcoidosis
A rare condition that makes small patches of red and swollen tissue called granulomas develop in the organs of the body. It usually affects the lungs, skin and eyes.
How are autoimmune eye diseases diagnosed?
Getting autoimmune diseases treated as soon as possible is really important. This can stop them from getting worse and reduce your discomfort. Unfortunately, getting a diagnosis for immune disorders can be difficult – the symptoms can often be mistaken for other conditions.
If your GP thinks your immune system is attacking your eyes, they might refer you to an eye specialist (optometrist or ophthalmologist) or an immune system doctor (rheumatologist or immunologist). They'll use a few methods to try to work out what's happening:
Medical history – The doctor will want to know when the symptoms began and ask for information about what it feels like. They'll also ask about symptoms in other parts of your body.
OCT scan – This detailed eye scan shows damage to the retina or optic nerve, which can be linked to some immune disorders. Available in our stores across the UK.
Slit lamp exam – A slit lamp is a powerful microscope with a lamp attached. Again, it allows optometrists to closely inspect your eyes and spot signs of autoimmune eye conditions. Learn more about eye tests.
MRI – This scan uses magnetic fields to create 3D images of your eyes, helping spot signs of some autoimmune disorders.
Computed tomography (CT) – CT scans are somewhat similar to MRI scans, but they use X‑rays to create an image of the inside of your eye and the tissues around it. This can help identify signs of an autoimmune disorder.
Blood tests – To help diagnose some autoimmune disorders, immunologists may take a sample of your blood. These will be sent to a lab to look for signs of an autoimmune disease.
Treatment of autoimmune eye diseases
If you're diagnosed with an autoimmune disease affecting your eyes, your GP or the specialist you speak to will create a treatment plan. Your doctor will guide you through the common medical treatments – we've provided examples of these below. Be aware that different immune diseases often have very specialised treatments, so this isn't a complete list.
Common medical treatments
Anti‑inflammatories and corticosteroids – These medications can reduce your immune system's inflammatory response. They can make flare‑ups less uncomfortable.
Immunosuppressants – These are powerful drugs that really slow your immune system down. They can help with managing flare‑ups. But they can have unpleasant side effects.
Surgery – If an immune disorder causes problems like cataracts or glaucoma from uveitis, surgery may be needed.
Dietary change – Sometimes, your rheumatologist may refer you to a nutritionist for dietary advice. Making some changes to your diet can potentially help with treating some kinds of autoimmune diseases.
Home remedies and self‑care for autoimmune eye inflammation
Depending on your symptoms and your doctor's recommendations, some of the following self‑care and home remedies can help with flare‑ups of autoimmune diseases affecting the eyes:
Sunglasses – If your eyes feel especially sensitive to light when you have a flare‑up, wearing sunglasses can help, particularly when spending time outdoors.
Artificial tears – Lubricating eye drops can ease dryness, discomfort and scratchiness during an autoimmune flare‑up.
Humidifiers – Again, if you have dry eyes, it can be helpful to use a humidifier. These devices release moisture into the air in your home. That means tears don't evaporate as quickly from your eyes.
Lifestyle choices – Good sleep, stress management, less alcohol and not smoking can help reduce flare‑ups and discomfort.
Regular eye tests – By having your eyes checked regularly by an optometrist, they'll be able to spot any changes in your eyes and give you advice on how to relieve many kinds of discomfort.
When your immune system affects your eyes
There are many autoimmune diseases that can affect vision. If you have an autoimmune condition and notice anything unusual with your eyes, it’s really important to get this checked by your GP, an optometrist, or an immune disorder specialist. Some autoimmune diseases can lead to serious eye problems if left untreated, including, in rare cases, loss of sight.
Autoimmune eye disease FAQs
Most autoimmune diseases don't cause complete vision loss. However, if left untreated, some could gradually damage the optic nerve and potentially cause blindness. This is particularly a risk for things like multiple sclerosis. Others may also make your vision worse.
While both conditions can be linked to autoimmune disorders, they affect different parts of the eye:
Optic neuritis is inflammation of the optic nerve. It can be painful, but it often causes vision changes such as blurred or dim vision.
Uveitis is inflammation of the middle part of the eye (the uvea). It usually causes a painful, red eye and can also lead to floaters or blurred vision.
Yes, autoimmune eye disorders often require long‑term treatment. Often, this can be done with self‑care and management – and by avoiding things that are likely to trigger flare‑ups.
If you have Sjogren's syndrome, one of the main symptoms is dry eyes. This can be treated in different ways, including by using eye drops, not smoking, staying away from dry or windy environments, and not staring at screens or books for a long time.
Optometrists can spot the signs of some autoimmune diseases. At Specsavers, our optometrists are trained to spot the symptoms and know how to use OCT scans and other equipment to diagnose these disorders. That being said, diagnosis often requires input from a few different experts, and you might need some other types of tests too.
Several autoimmune disorders can affect your eyes in different ways. Some of the autoimmune disorders that often affect the eyes include rheumatoid arthritis, Sjogren's syndrome, Reiter's syndrome, Bechet's disease, sarcoidosis, multiple sclerosis and Graves' disease.
Yes, if you believe your immune system is attacking your eyes, you should see your GP. If you've already been diagnosed with an autoimmune disorder, they can try to work out what's causing these symptoms and suggest treatments.
Related conditions
Not sure if this is what you’re experiencing? Explore some related conditions:
Corneal Abrasion
A corneal abrasion is a scratch to the cornea, and can often cause discomfort, red eyes, and a strong sensitivity to light.
Find out moreIritis
Iritis, or anterior uveitis, is an inflammation of the iris – the coloured part of your eye that controls the size of your pupil.
Find out moreEye Pain
There are different types of eye pain including sharp, stabbing, throbbing or dull pain ‑ knowing what type can help determine the cause and how to treat it.
Find out more
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Foster, S. (2023) Ocular Autoimmune Disease: An Introduction. Available at: https://uveitis.org/patient_articles/ocular‑autoimmune‑disease‑introduction/
Glover, K., et al. (2021) Epidemiology of Ocular Manifestations in Autoimmune Disease. Available at: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.744396/full
Patel, S. et al. (2002) Ocular manifestations of autoimmune disease. Available at: https://www.aafp.org/pubs/afp/issues/2002/0915/p991.html
Rath, L. (2023) Dry eyes with immune disorders. Available at: https://www.webmd.com/eye‑health/dry‑eyes‑immune‑system‑disorders
